The posting, in Generate Biomedicines's own words
archived Oct 19, 2026The Role:
Generate:Biomedicines is seeking a Scientist I with expertise in cancer biology to support the discovery and development of protein-based oncology therapeutics. As a member of a multidisciplinary team, this individual will plan and execute cellular assays, interpret results, and generate reproducible data that inform project decisions. This highly laboratory-focused role requires sound scientific judgment, rigorous documentation, and effective collaboration. The core focus will be oncology, with opportunities for a curious scientist to expand their drug discovery and development experience across other therapeutic areas as project needs evolve.
Here's how you will contribute:
Establish, maintain, and characterize cancer cell lines, tumor organoids, and primary cells, including cells from primary human tumor samples, to support target validation and therapeutic evaluation. Generate and validate engineered cell lines using approaches such as transfection, transduction, and CRISPR-based editing to modulate target expression or introduce assay reporters. Design, execute, and troubleshoot assays of cell viability, proliferation, cytotoxicity, target binding, and receptor or antibody internalization, including tumor and immune cell co-cultures where appropriate. Apply flow cytometry, live-cell imaging, plate-based assays, and immunoassays such as ELISA, AlphaLISA, and Meso Scale Discovery (MSD), together with molecular biology and biochemistry techniques, to characterize therapeutic activity and mechanism of action. Analyze, interpret, and present experimental findings, recommending next steps that support project decisions and pipeline progression. Collaborate with cross-functional partners in Automation, Computational Sciences, Protein Sciences, and High-Throughput Screening to advance shared project goals. Maintain complete and accurate experimental records and stay current with relevant advances in oncology, immuno-oncology, and biologics research.
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The Ideal Candidate will have:
Ph.D. in cancer biology, cell biology, immunology, immuno-oncology, or a related field; or a master’s degree in a related field with six years of relevant experience; or a bachelor’s degree in a related field with eight years of relevant experience; or eleven years of relevant experience. Strong foundation in cancer biology and hands-on mammalian cell culture expertise, including work with cancer cell lines and primary cells. Hands-on experience with in vivo tumor models, such as xenograft, patient-derived xenograft (PDX), or syngeneic models, including assessment of tumor growth, treatment response, and pharmacodynamic biomarkers. Experience with cell line engineering and standard molecular biology and biochemistry techniques, such as cloning, PCR/RT-qPCR, and Western blotting. Experience developing and troubleshooting quantitative cell-based assays, including cytotoxicity, viability, or internalization assays. Proficiency in flow cytometry and experience measuring proteins or cytokines using platforms such as ELISA, AlphaLISA, or MSD. Ability to independently plan experiments, select appropriate controls, analyze and interpret quantitative data, and recommend follow-up studies. Experience communicating scientific findings and collaborating within a multidisciplinary project team.