The posting, in NewLimit's own words
archived Oct 21, 2026About NewLimit
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Position
We are seeking a Scientist to lead downstream process development for the mRNA Engineering team. In this role, you will design, optimize, and scale purification processes for mRNA drug substance. This is a hands-on, lab-based role that spans program process development and platform engineering. It is ideal for a scientist who enjoys solving purification challenges and scaling processes in a dynamic, fast-paced environment.
Read the full posting ↓
As a member of our team, you will:
Develop downstream purification processes Design, execute, and analyze process development studies for mRNA purification Act as the downstream lead for CMC program teams Help design and implement automated downstream workflows for high-throughput purification of research-grade mRNA Support execution of research-grade mRNA production runs for discovery and preclinical studies, as needed Support process scale-up from bench to pilot scale, as needed Evaluate emerging purification technologies and chromatography resins Support tech transfer and CDMO manufacturing Perform tech transfer of downstream processes to CDMOs Act as person in plant during CDMO manufacturing runs Support process troubleshooting and deviation investigations at CDMOs Documentation and collaboration Maintain organized experimental records in Electronic Lab Notebooks Author development SOPs and technical development reports Present experiment results at team meetings
Requirements
Ph.D. in analytical chemistry, biochemistry, molecular biology, chemical engineering, or a related field with 0–3 years of relevant industry experience, or an M.S. with 5+ years or B.S. with 7+ years of relevant industry experience Hands-on experience developing downstream purification processes for nucleic acids or other biologics Hands-on experience with tangential flow filtration (TFF) Experience operating ÄKTA chromatography systems Ability to independently design, execute, and troubleshoot experiments Ability to analyze and present complex data sets Strong technical writing skills Excellent communication and organizational skills