The posting, in Revolution Medicines's own words
archived Nov 3, 2026Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide. Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.
The Opportunity:
As a key member of our dynamic Mechanism of Action team within Discovery Biology under the Biomedical Discovery Research (BDR) department, you will have responsibilities including, but not limited to: Perform label-free biophysical assays (BLI, SPR) to inform the mode of action of small molecule and tri-complex inhibitors. Assist in the development and troubleshooting of SPR methods for novel applications. Assist in the transfer of established methods for routine screening. Perform data analysis, prepare experimental result reports, upload data to electronic notebooks, and present findings to project teams. Support laboratory operations, including lab safety, instrument maintenance, and ordering of essential consumables.
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Required Skills, Experience and Education:
BSc or MS in biological sciences or a related scientific discipline, with 5+ years of industry experience for BSc holders or 3+ years for MSc holders. Hands-on experience in operating and maintaining SPR (Cytiva Biacore or Carterra LSA) and BLI (Octet or Gator) systems. Hands-on experience in SPR/BLI method development and data analysis. Hands-on experience in working diverse sample types (cell lysates, purified proteins, clarified supernatant). Ability to customize and follow established assay protocols. Ability to manage multiple laboratory and project tasks efficiently. Ability to work effectively in a flexible, team-oriented environment. Highly organized and detail-oriented, with excellent recordkeeping skills and the ability to adapt to a dynamic, fast-paced environment.